CYANOCOBALAMIN (VITAMIN B12)
Shape and Properties
This product is a crimson crystal or crystalline powder, odourless, tasteless and has strong moisture-inducing properties. Slightly soluble in water or ethanol, insoluble in chloroform or ether. Heat-resistant, but it can be ineffective when exposed to oxidising or reducing substances (such as vitamin C or hydrogen peroxide, etc.), heavy metal salts and strong acids and strong alkalis.
Chemical Structure
Vitamin B12 is an equioctaphedral compound containing cobalt ions. Its central structure is a flat corrin ring composed of four pyrroles connected. The molecules of vitamin B12 are roughly composed of 3 parts: a gourin ring chylated by four N atoms and central cobalt ions; 5,6-dimethylbenzimidazole (5,6-dimethylbenzimidazole, DMBI) connected to N-7 atoms and cobalt ions as vitamin B 12 molecules of low-level (α) ligands. In addition, DMBI is also connected to aminopropanol through phosphate groups, and aminopropanol is covalently connected to the propionic acid side chain on pyrrole D; adenosyl group or methyl group It is connected with cobalt ions to form the upper (β) ligand of vitamin B12 molecules. Different types of vitamin B12 substances are formed when the group of the chemical book is different from the upper chemical book on the axis of the goline ring. The hydroxyl group (-OH) is connected to the cobalt ion in the gluline ring to form hydroxycobalamin. Similarly, deoxyadenosine (5'-deoxyadenosyl), methyl (-CH3), cyanide (-CN) and cobalt ions are connected to produce adenosine cobalt respectively. Amine (deoxyadenosylcobalamin), methylcobalamin (methylcobalamin) and cyanocobalamin (cyanocobalamin). In nature, the final form of vitamin B12 biosynthesised by microorganisms is adenosine cobalamine (coenzyme B12), methyl cobalamine and hydroxycobalamine. However, because their properties are not very stable, sodium cyanide is artificially added in the industrial purification process to convert the natural form of vitamin B12 into more stable cyanocobalamin.
Physiological Function
Improve the utilisation rate of folic acid, synthesise meththionine (synthesised from high cysteineine) and choline with folic acid, and synthesise cyanocobalamin precursors such as methyl coballamin and coenzyme B12 in the process of producing prine and pyrimidine, and participate in the methylation process of many important compounds. When vitamin B12 is deficient, the activity of transferring methyl groups from methyl tetrahydrofolic acid is reduced, making folic acid an unuseable form, leading to folic acid deficiency. Maintain the metabolism and function of nerve myelin sheath. Lack of vitamin B12 can cause neurological disorders, spinal degeneration, and chemical book can cause serious mental symptoms. Vitamin B12 deficiency can lead to peripheral neuritis. The early manifestations of vitamin B12 deficiency in children are abnormal mood, sluggish expression, slow reaction, and finally lead to anaemia. Promote the development and maturity of red blood cells. Methylpropandiyl coenzyme A is converted into succinoyl coenzyme A and participates in the tricarboxylic acid cycle, in which succinyl coenzyme A is related to the synthesis of heme. Vitamin B12 also participates in the synthesis of deoxynucleic acid (DNA), the metabolism of fat, carbohydrates and protein, and increases the synthesis of nucleic acids and proteins.
